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Doctors are also mislead by big pharma on a regular basisMAHAImportant truths about GabapentinSystematic reviews show statistically significant but clinically trivial reductions in pain and opioid use overall (Anesthesiology 2020), with meaningful benefit limited to a few surgical contexts. What is consistent is harm: combining gabapentin with opioids increases overdose risk due to respiratory depression (PLOS Medicine, 2017), along with higher rates of dizziness, delirium, pneumonia, and antips
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Statistically significant does not mean clinically significant. In the latest Stats, Stat! animated video from 𝘕𝘌𝘑𝘔 𝘌𝘷𝘪𝘥𝘦𝘯𝘤𝘦, Nigam and colleagues explain the minimal clinically important difference. | The New England Journal of Medicine
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